Table 2 Information extracted from each article type
Article type | Information extracted |
|---|---|
Clinical effectiveness paper | Overall survival (OS) • Endpoint level (primary, secondary, exploratory, unclear) • Definition • The analysis used for the interpretation of the primary endpoint • Whether a Kaplan-Meier Plot for OS was included ○ Whether an at-risk table was included with the plot ○ Whether the at-risk table included the number censored/number of events ○ Whether confidence intervals were included on the plot • Whether a logrank test for OS was conducted ○ Whether the test was adjusted or unadjusted for other factors. • Whether a Cox proportional hazards model for OS was included ○ Whether the results were adjusted or unadjusted for other factors. Subsequent treatmenta • Whether the number or percent of trial participants receiving treatment in follow-up is included in the results or appendix. • Whether a summary of the number of treatment lines and/or types of treatments trial participants received. • Whether subsequent treatments are discussed in the discussion. ○ If yes — what are their thoughts? • Whether they did some form of analysis to account for subsequent treatments. ○ If yes — what analysis? |
Cost-effectiveness paper | Cost-effectiveness • What OS results fed into the cost-effectiveness analysis and how were they determined. Subsequent treatment • Whether subsequent treatment costs were incorporated into the cost-effectiveness analysis • Whether subsequent treatments are discussed in the discussion. ○ If yes — what are their thoughts? • Whether they did some form of analysis to account for subsequent treatments. ○ If yes — what analysis? |
Methodology/review paper | General information • Treatment overview or methodology paper? Subsequent treatment • Whether subsequent treatments are discussed. ○ If yes — what are their thoughts? |