Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial

Table 3 Duration of treatment according to extent-of-TB-disease phenotype at screening/baseline

Any lung cavity	Screening sputum AFB smear grade
Any lung cavity	Negative or scanty	1 +	2 +	3 +
Cavity absent	24 weeks of treatment^a	24 weeks of treatment^a	39 weeks of treatment	39 weeks of treatment
Cavity present	24 weeks of treatment^a	39 weeks of treatment	39 weeks of treatment	39 weeks of treatment

Abbreviation: AFB acid-fast bacilli. Screening sputum AFB smear grade is assigned based on the highest smear grade from a screening (or baseline) sputum sample (N = 3). Cavitary disease is defined as the presence of at least one lung cavity on the baseline chest radiograph
^aThese participants might have treatment extended to 39 weeks based on treatment response, defined by sputum culture results assessed at week 8 or between week 8 and week 24

ISSN: 1745-6215