Table 1 1- and 3-h bundle elements: quality and outcome indicator definitions and specifications
Definition of bundle element (quality indicator) or outcome measure obtained from the EHR by site staff | Both study arms | |
|---|---|---|
Bundle element | ||
1 | Indicate if patient with sepsis or septic shock had an initial lactate drawn | Initiated or completed within 1 or 3 h following the time of presentation in the ED |
2 | Indicate if patient had blood cultures collected prior to broad-spectrum antibiotics for sepsis and/or septic shock | Initiated or completed within 1 or 3 h following the time of presentation in the ED |
3 | Time in minutes to receipt of broad-spectrum antibiotics for sepsis and/or septic shock following the time of presentation in the ED | Initiated or completed within 1 or 3 h following the time of presentation in the ED |
4 | Indicate if patient had 30 ml/kg IVF bolus initiated if hypotensive or with a lactate ≥ 4 mmol/L on presentation in the ED | Initiated or completed within 1 or 3 h following the time of presentation in the ED or n/a |
5 | Indicate if patient with persistent hypotension received vasopressors to achieve mean arterial pressure > 65 mmHg | Initiated or completed within 1 or 3 h following the time of presentation in the or n/a |
6 | The percent of cases of sepsis and/or septic shock that completed all elements of the bundle | Initiated or completed within 1 or 3 h following the time of presentation in the ED |
7 | The percent of all patients that completed all elements of the bundle | Initiated or completed within 1 or 3 h following the time of presentation in the ED |
Outcome measures | ||
A | Hospital mortality for patients with sepsis and/or septic shock (primary outcome) | Yes vs. no |
B | Hospital days for patients with sepsis and/or septic shock | Count |
C | Indicate if mechanical ventilation present during admission for patients with sepsis and/or septic shock | Yes vs. no |
D | Days alive and free from mechanical ventilation | Count |