Comparison of three regimens with inhalational methoxyflurane versus intranasal fentanyl versus intravenous morphine in pre-hospital acute pain management: study protocol for a randomized controlled trial (PreMeFen)

Table 3 Schedule of activities

Timepoint	T(x)	T₀	T₅	T₁₀	T₂₀	T₃₀	T_ED	Within 14 days
Description	Scene arrival	IMP adm	5 min	10 min	20 min	30 min	Arrival ED
Inclusion and exclusion criteria	X
Informed oral consent	X
Physical examination including estimation of weight	X
Medical history	X
Allocation	X
ECG (If chest pain)	(X)						(X)
Intravenous access attempts	X
Start administration of IMP		X
SpO₂	X			X	X	X	X
Blood pressure	X			X		X	X
Heart rate	X			X	X	X	X
Respiration rate	X			X		X	X
NRS	X		X	Primary endpoint	X	X	X
GCS	X			X		X	X
Patient satisfaction Likert scale							X
HCP satisfaction Likert scale							X
Troponin I/T							X
Recording final diagnosis								X

IMP Investigational medicinal product, ECG Electrocardiogram, SpO₂ Oxygen saturation, NRS Numeric rating scale, GCS Glasgow come scale, HCP Health care personnel

ISSN: 1745-6215