Table 1 Inclusion and exclusion criteria

• Diagnosis of Autosomal Dominant Polycystic Kidney Disease

• Age > 18 years old

• eGFR > 30 mL/min/1.73 m²

• Treatment with at least 1 anti-hypertensive

• Inability to provide informed consent

• Labile, unstable, uncontrolled hypertension and/or changes in BP treatment 28 days prior to the screening visit

• Non-compliance with study procedures and/or daily BP measurements during the screening period

• Medical conditions or treatments that might interfere with the generation of NO metabolites or the primary endpoint (e.g. nitrate drugs, cigarette smoking; unwilling to stop using antiseptic mouthwash; severe, uncontrolled hypercholesterolaemia; pregnancy or post-partum and lactating)

• Any serious or other medical conditions that might interfere with follow-up or stability of blood pressure (e.g. current active malignancies; uncontrolled diabetes mellitus with elevated HbA1c > 10%)

• Dislike of taste of BRJ

• Allergy to beetroot

• Enrolled in other clinical trials