Table 2 Key design feature comparison between countries

Study population – index patients

Clinically diagnosed and bacteriologically confirmed pulmonary TB patients

Bacteriologically confirmed pulmonary TB patients

Study population – child contacts

Children < 15 years of age

Children < 5 years of Age

TPT regimen^a

3HP for those ³ 2 years

3RH for those < 2 years

6H for those on ART

3RH for those 0-5 years

6H for those on ART

Community-based care model

Health extension worker based at health post in the community

Outreach team leader (professional nurse) teamed with community health worker

TPT initiation and follow-up

Performed by health extension worker;

Task-shared with clinic TB focal person

Performed by professional nurse;

Task-shifted from clinic TB focal nurse to a community-based health nurse

Persons responsible for TPT initiation and follow-up during trial

Utilized health system’s TB focal persons and health extension workers

Research nurse and clinic’s TB focal person

HIV testing

Not performed at household visits

Performed at household visits