Optimising DTwP-containing vaccine infant immunisation schedules (OptImms) — a protocol for two parallel, open-label, randomised controlled trials

Table 5 Non-inferiority margins based on varying standard deviations (SDs)

Standard deviation	Non-inferiority margin on Log₁₀ scale
Standardised standard deviation (SD = 1) on the Log₁₀ scale	− 0.35 (Cohen’s d)
Assuming an SD of 0.6 on the Log₁₀ scale [20]	− 0.21 (equivalent to a GMR of 0.62)
Assuming an SD of 0.2 on the Log₁₀ scale [23]	− 0.07 (equivalent to a GMR of 0.85)

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