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Table 1 Objectives of the Nonalcoholic Fatty Liver Disease-Intermittent Calorie Restriction (FLICR) study

From: Effect of 12-week intermittent calorie restriction compared to standard of care in patients with nonalcoholic fatty liver disease: a randomized controlled trial

 

Study time points (weeks)

Intervention period

Maintenance period

0

6

12

24

Primary objective

 Change in liver steatosis by MRI-PDFF

 

 

Secondary objectives

 Change in liver fibrosis by MRE

 

 

 Change in anthropometrics

 

  Change in BCA by InBody

 

  Change in VAT by fat CT

 

  Change in quality of life score by CLDQ

 

  Change in hormone

 

 

  Change in liver metabolites

 

 

  Change in gut microbiota by 16S rRNA gene sequencing

 

 

 Polymorphism of SNPs using NGS

   
  1. MRI Magnetic resonance imaging, PDFF Proton density fat fraction, MRE Magnetic resonance elastography, BCA Body composition analysis, VAT Visceral adipose tissue, CT computed tomography, CLDQ Chronic Liver Disease-NAFLD Questionnaire, SNP Single nucleotide polymorphism, NGS Next-generation sequencing