Study time points (weeks) | ||||
---|---|---|---|---|
Intervention period | Maintenance period | |||
0 | 6 | 12 | 24 | |
Primary objective | ||||
Change in liver steatosis by MRI-PDFF | ■ | ■ | ||
Secondary objectives | ||||
Change in liver fibrosis by MRE | ■ | ■ | ||
Change in anthropometrics | ■ | ■ | ■ | |
Change in BCA by InBody | ■ | ■ | ■ | |
Change in VAT by fat CT | ■ | ■ | ■ | |
Change in quality of life score by CLDQ | ■ | ■ | ■ | |
Change in hormone | ■ | ■ | ||
Change in liver metabolites | ■ | ■ | ||
Change in gut microbiota by 16S rRNA gene sequencing | ■ | ■ | ||
Polymorphism of SNPs using NGS | ■ |