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Table 4 Power calculations for secondary outcomes

From: Hyperhydration to Improve Kidney Outcomes in Children with Shiga Toxin-Producing E. coli Infection: a multinational embedded cluster crossover randomized trial (the HIKO STEC trial)

Outcome

Power

Detectable difference with 20 sites

(n = 800)

Detectable difference with 26 sites

(n = 1040)

Hemolytic uremic syndrome—17.5% in conservative fluid management arm

80%

7.2%

6.3%

90%

8.1%

7.1%

Extrarenal complications—7.5% in conservative fluid management arm

80%

4.7%

4.1%

90%

5.2%

4.6%