Fig. 3From: Hyperhydration to Improve Kidney Outcomes in Children with Shiga Toxin-Producing E. coli Infection: a multinational embedded cluster crossover randomized trial (the HIKO STEC trial)The hyperhydration care pathway recommends the infusion of 200% maintenance fluids until a hematocrit reduction of 20% and weight gain of 10% occur. Patients may be discharged if the following criteria are met even if the targets are not achieved: (1) platelet count is > 50 × 109/L (in absence of transfusion) AND they have increased by ≥ 5%* since the preceding test AND (2) absence of diarrhea (loose or watery stool) × 24 h AND (3) ≥ 5 days since the onset of diarrhea. *If > 10 days since the onset of diarrhea, up to a 5% decrease in platelet count since preceding test is acceptableBack to article page