Table 1 Definition of eligibility criteria used for the semi-synthetic simulations based on the TCGA dataset. The more restrictive eligibility criteria exclude patients with comorbidities who can be expected to have worse outcomes. N denotes the number of TCGA patients who meet the eligibility criteria
From: More efficient and inclusive time-to-event trials with covariate adjustment: a simulation study
Eligibility level | Nested inclusion criteria | N (%) |
|---|---|---|
Less restrictive | All TCGA patients selected for HCCnet validation [15] | 328 (100%) |
Mildly restrictive | Child Pugh classification is A ECOG \(\le\) 1 | 270 (82%) |
Most restrictive | ECOG score of 0 No macrovascular invasion No cumulated hepatitis B and C infection | 169 (52%) |