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Table 4 Primary reason eligible patients not enrolled prior to COVID-19 and during COVID-19

From: The impact of the COVID-19 pandemic on ICU clinical trials: a description of one research team’s experience

Reason not enrolled

Frequency prior to COVID

Frequency during COVID

Legally authorized representative declined consent

    Both sites total

27%

16%

    Mayo Clinic

14%

17%

    University of Minnesota

38%

15%

Patient declined consent

    Both sites total

51%

59%

    Mayo Clinic

60%

71%

    University of Minnesota

44%

45%

No legally authorized representative available

    Both sites total

7%

4.5%

    Mayo Clinic

7%

0%

    University of Minnesota

6%

10%

Primary patient care team declined enrollment

    Both sites total

11%

14%

    Mayo Clinic

19%

12.5%

    University of Minnesota

4%

15%

Study physician declined enrollment

    Both sites total

0%

4.5%

    Mayo Clinic

0%

0%

    University of Minnesota

0%

10%

Other

    Both sites total

4%

0%

    Mayo Clinic

0%

0%

    University of Minnesota

8%

0%

Patient withdrew consent after enrollment

    Both sites total

0%

2%

    Mayo Clinic

0%

0%

    University of Minnesota

0%

5%

  1. Overall differences between distributions Fisher’s exact test both sites total P = 0.11
  2. Overall differences between distributions Fisher’s exact test Mayo Clinic P = 0.48
  3. Overall Differences between distributions Fisher’s exact test University of Minnesota P = 0.03*