Table 2 Screen failures prior to COVID-19 and during COVID-19 Mayo Clinic

Hypotension outside eligibility parameters

167 (11%)

154 (7%)

 < 0.0001*

Paralysis/unable to use push-button device

35 (2.5%)

49 (2%)

0.78

Acute stroke/seizures

83 (6%)

53 (2%)

 < 0.0001*

Cognitive impairment

44 (3%

20 (1%)

 < 0.0001*

Coma

21 (1.5%)

3 (0.1%)

 < 0.0001*

Dementia

36 (2.5%)

45 (2%)

0.4

RASS outside eligibility parameters

402 (27%)

734 (32%)

0.0006*

Chronic ventilator support in residence

32 (2%)

28 (1%)

0.3

Language barrier

60 (4%)

108 (5%)

0.33

Chemical paralysis

22 (2%)

23 (1%)

0.22

No sedation in previous 24 h

127 (9%)

120 (5%)

0.0001*

Unable to follow simple commands

139 (9%)

148 (7%)

0.00017*

Need for multiple sedative medications

33 (2%)

13 (0.6%)

 < (0.0001*

ECMO COVID patients in CV (ICU)

2 (0.1%)

0 (0%)

0.16

Alcohol withdrawal protocol requiring specific sedative medications

71 (5%)

45 (2%)

 < (0.0001*

Temporary pacemaker/severe bradycardia

0 (0%)

0 (0%)

––

Procedure(s) requiring heavy sedation

56 (4%)

34 (2%)

 < (0.0001*

Documented research opt-out

0 (0%)

1 (0%)

––

COVID-19 positive

–––

524 (23%)

––