Protocol of a prospective multicenter randomized controlled trial of robot-assisted stereotactic lesioning in the treatment of focal drug-resistant epilepsy

Table 1 Participant timeline

Study period	Enrollment	Allocation	Operation	Follow-up	Follow-up	Follow-up	Follow-up
Time point	− 10 days	− 7 days	0	7 ± 2 days	90 ± 7 days	180 ± 14 days	365 ± 14 days
Participants
Eligibility screen	X
Informed consent	X
Randomization	X
Demography		X
Interventions
MRI-guided stereotactic LITT group			X
Stereotactic EEG-guided RF-TC group			X
Resective surgery group			X
Outcomes
Seizure remission rate					X	X	X
Engel classification							X
ASMs		X		X	X	X	X
Neurological function examination		X		X	X	X	X
Scalp EEG		X			X	*X	X
NISHH		X					X
WAIS-IV-C/WCIS-IV-C		X					X
WADS-IV-C/WCDS-IV-C		X					X
QOILE-89/QOILE-48		X					X
PET		*X					*X
MRI		X			X	*X	X
Operative information			X				X
Adverse events				X	X	X	X

X, required; *X, optional; LITT Laser interstitial thermal therapy, EEG Electroencephalography, RF-TC Radiofrequency thermocoagulation, ASM Anti-seizure medications, WAIS-IV-C Chinese version of the Wechsler Adult Intelligence Scale-IV, WCIS-IV-C Chinese version of the Wechsler Children’s Intelligence Scale-IV, WAIS-IV-C Chinese version of the Wechsler Adult Development Scale-IV, WCIS-IV-C Chinese version of the Wechsler Children’s Development Scale-IV, QOLIE-89 Quality of Life in Epilepsy-89, QOLIE-48 Quality of Life in Epilepsy-48, PET positron emission tomography, MRI Magnetic resonance imaging

ISSN: 1745-6215