Skip to main content

Table 2 Intervention components and study conditions in the fractional factorial design

From: Protocol for an evaluation of adherence monitoring and support interventions among people initiating antiretroviral therapy in Cape Town, South Africa—a multiphase optimization strategy (MOST) approach using a fractional factorial design

Study condition

Intervention components

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

Core (standard care): After a VL test shows unsuppressed virus, the patient is alerted at the next clinic visit and given a counselling session

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

M1. Call to the patient after VL test result of unsuppressed virus (M1/Call)

O

O

O

O

O

O

O

O

X

X

X

X

X

X

X

X

M2. Pharmacy refill monitoring + Call to the patient (M2/PRM)

O

O

O

O

X

X

X

X

O

O

O

O

X

X

X

X

M3. Electronic adherence monitoring + Call to the patient (M3/EAM)

O

O

X

X

O

O

X

X

O

O

X

X

O

O

X

X

S1. Weekly check-in text messages (S1/Text)

O

X

O

X

O

X

O

X

O

X

O

X

O

X

O

X

S2. Peer support counselling: Basic (B) or Enhanced (E) (S2/Peer)

E

B

B

E

B

E

E

B

B

E

E

B

E

B

B

E

  1. Abbreviations: VL, viral load; PRM, pharmacy refill monitoring; EAM, electronic adherence monitoring