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Fig. 1 | Trials

Fig. 1

From: A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT

Fig. 1

Tacrolimus (TAC) dosing during the interventional phase of the TTVguideIT study: In the active/interventional group, the tacrolimus trough level range will be adapted by torque teno virus (TTV) load. The target TTV load ranges from 4.6 log10 copies per millilitre (c/mL) to 6.2 log10 c/mL as the optimal range. If TTV is not within the optimal range, the TAC trough level target has to be adapted by one step up (only if the patient is adherent to TAC intake) or down compared to the current TAC trough level. One TAC trough level adaption step is defined as 2±1 ng/mL. Additional rules are detailed in the trial protocol. In the control group, TAC will be dosed according to TAC trough levels defined by the local centre standard

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Trials

ISSN: 1745-6215