Table 1 Summary statistics for HARP-2, ALTA, EDEN and SAILS
From: Re-analysis of ventilator-free days (VFD) in acute respiratory distress syndrome (ARDS) studies
Study | VFD score | VFD score for survivorsa | VFD score for patients achieving UBb | ||||||
|---|---|---|---|---|---|---|---|---|---|
HARP-2 | All | Placebo | Simvastatin | All | Placebo | Simvastatin | All | Placebo | Simvastatin |
N | 537 | 279 | 258 | 405 | 204 | 201 | 353 | 170 | 180 |
Mean (SD) | 12.0 (10.2) | 11.5 (10.4) | 12.6 (9.9) | 15.9 (8.70) | 15.8 (9.1) | 16.1 (8.3) | 18.2 (6.6) | 18.7 (6.4) | 17.8 (6.8) |
Median (IQR) | 13 (0, 22) | 12 (0, 22) | 14 (0, 22) | 19 (10 to 23) | 19 (9, 23) | 19 (10, 23) | 20 (14, 23) | 20 (14, 24) | 20 (14, 23) |
Min to Max | 0 to 27 | 0 to 27 | 0 to 27 | 0 to 27 | 0 to 27 | 0 to 27 | 2 to 27 | 2 to 27 | 2 to 27 |
ALTA | All | Placebo | Albuterol | All | Placebo | Albuterol | All | Placebo | Albuterol |
N | 282 | 130 | 152 | 233 | 112 | 121 | 205 | 102 | 103 |
Mean (SD) | 15.4 (10.6) | 16.6 (10.0) | 14.4 (11.1) | 18.6 (8.7) | 19.3 (8.1) | 18.0 (9.4) | 21.2 (5.8) | 21.1 (5.6) | 21.2 (6.0) |
Median (IQR) | 20 (0, 24) | 21 (7, 24) | 20 (0, 24.5) | 22 (15 to 25) | 22 (17, 25) | 22 (13, 25) | 23 (19, 26) | 23 (17, 25) | 23 (19, 25) |
Min to Max | 0 to 28 | 0 to 28 | 0 to 28 | 0 to 28 | 0 to 28 | 0 to 28 | 2 to 28 | 2 to 28 | 2 to 28 |
EDEN | All | Full | Tropic | All | Full | Tropic | All | Full | Tropic |
N | 1000 | 492 | 508 | 806 | 397 | 409 | 696 | 351 | 345 |
Mean (SD) | 14.9 (10.8) | 15.0 (10.6) | 14.9 (10.9) | 18.5 (8.8) | 18.6 (8.5) | 18.5 (9.1) | 21.3 (5.5) | 21 (5.5) | 21.6 (5.4) |
Median (IQR) | 20 (0, 24) | 19.5 (0, 24) | 20 (0, 25) | 22 (15 to 25) | 22 (16 to 25) | 22 (15 to 25) | 23 (19, 25) | 23 (18, 25) | 23 (20, 25) |
Min to Max | 0 to 28 | 0 to 28 | 0 to 28 | 0 to 28 | 0 to 28 | 0 to 28 | 1 to 28 | 1 to 28 | 1 to 28 |
SAILS | All | Placebo | Rosuvastatin | All | Placebo | Rosuvastatin | All | Placebo | Rosuvastatin |
N | 745 | 366 | 379 | 573 | 285 | 288 | 515 | 251 | 264 |
Mean (SD) | 15.1 (10.9) | 15.1 (11.0) | 15.1 (10.8) | 19.6 (8.1) | 19.4 (8.5) | 19.8 (7.7) | 21.8 (5.2) | 21.9 (5.2) | 21.6 (5.1) |
Median (IQR) | 20 (0, 25) | 20 (0, 25) | 20 (0, 25) | 23 (17, 25) | 23 (17, 25) | 23 (17, 25) | 23 (20, 26) | 23 (20, 26) | 24 (19.5, 25.5) |
Min to max | 0 to 28 | 0 to 28 | 0 to 28 | 0 to 28 | 0 to 28 | 0 to 28 | 1 to 28 | 2 to 28 | 1 to 28 |