Characterizing modifications to a comparative effectiveness research study: the OPTIMIZE trial—using the Framework for Reporting Adaptations and Modifications to Evidence-based Interventions (FRAME)

Peer Review reports

Original Submission
2 Jun 2022	Submitted	Original manuscript
11 Nov 2022	Reviewed	Reviewer Report - Joy Adamson
19 Dec 2022	Reviewed	Reviewer Report - Research Square Reviewer 1
17 Jan 2023	Author responded	Author comments - Tom Greene
Resubmission - Version 2
17 Jan 2023	Submitted	Manuscript version 2
Publishing
8 Feb 2023	Editorially accepted
23 Feb 2023	Article published	10.1186/s13063-023-07150-1

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