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Table 1 List of allowed antibiotic treatments (empirical or targeted)

From: Study protocol: short against long antibiotic therapy for infected orthopedic sites — the randomized-controlled SALATIO trials

Antibiotic

Allowed dosing regimens

Allowed total daily dose range

Levofloxacin PO

750 mg q.24h or 500 mg q.12h

750 to 1500 mg

Ciprofloxacin PO

750 mg q.24h or 500 mg q.12h

750 to 1500 mg

Amoxicillin/clavulanate IV

1000/200 mg q.8h

2000/400 mg to 3000/600 mg

Cefuroxim IV

1500 mg q.8h

4500 mg

Ceftriaxon IV

2000 mg q.24 h

2000 mg

Co-trimoxazole PO

960 mg q.12h or q.8h

1920 mg to 2880 mg

Clindamycin PO

300 mg or 450 mg q.6h

1200 mg to 1800 mg

Doxycyclin PO

100 mg q.12h

200 mg

Minocyclin PO

100 mg q.12h

200 mg

Linezolid PO

600 mg q.12h

1200 mg

Metronidazole PO

500 mg q.8h

1500 mg

Vancomycin IV

15 mg/kg q.12h

According to serum through levels

Daptomycin IV

8 mg/kg/day

6–10 mg/kg/day

Cefepime IV

2000 mg q.12h

4000 mg

Imipenem IV

500 mg or 1000 mg or q.8h or q.6h

2000 mg to 3000 mg

Meropenem IV

2000 mg q.8h

1000 mg q.8h

Piperacillin/tazobactam IV

4000/500 mg q.8h

12,000/15,000 mg (12 g/1.5 g)

  1. PO oral therapy, IV intravenous therapy