Table 1 Criteria for clinical genetic testing for aim 2 randomized trial (adapted from NCCN)

Breast

i. Diagnosed age< 50 years

ii. PREMM risk model score ≥ 2.5%

iii. Personal history of triple-negative breast cancer

iv. Ashkenazi Jewish ancestry

v. Personal history of male breast cancer

vi. 1st or 2nd degree relative with ovarian cancer, pancreatic cancer, breast cancer diagnosed under 50, triple-negative breast cancer, or male breast cancer

Colorectal

i. Diagnosed under 50

ii. PREMM risk model score ≥ 2.5%

Prostate

i. Diagnosed age< 50 years

ii. PREMM risk model score ≥ 2.5%

iii. Ashkenazi Jewish ancestry

iv. 1st or 2nd degree relative with ovarian cancer, pancreatic cancer, breast cancer diagnosed under 50, or male breast cancer

Endometrium/uterine

i. Diagnosed age< 50 years

ii. PREMM risk model score ≥ 2.5%

Ovarian

No additional criteria needed

Pancreatic

No additional criteria needed