Table 2 SPIRIT figure—schedule of enrollment, interventions, and assessments

TIMEPOINT

 − t₁

0

t₁

t₂

t₃

t₄

t₅

t₆

t₇

t₈

t₉

ENROLLMENT:

Eligibility screen

X

Informed Consent

X

Allocation

X

INTERVENTIONS:

Stage 1 CM

X

X

X

X

Stage 1 BSM

X

X

X

X

Stage 2 Switch

X

X

X

X

Stage 2 Combine

X

X

X

X

ASSESSMENTS:

Baseline

Inclusion/exclusion

X

Contact information

X

X

X

X

X

X

X

X

X

Demographics

X

Opioid use disorder

X

Outcomes

Toxicology screen

X

X

X

X

X

X

X

X

X

Clinic visit attended

X

X

X

X

X

X

X

X

Moderators

Opioid Cravings Scale

X

X

X

X

X

X

X

X

X

X

TAPS Tool Part 1

X

X

Timeline Followback

X

X

X

X

X

X

X

X

Engagement in Substance-free activities

X

X

PEG for chronic pain

X

X

X

X

X

X

X

X

X

X

Brief Pain Inventory

X

X

EQ5D5L

X

X

PHQ-2 depression

X

X

X

X

X

X

X

X

X

X

GAD 2

X

X

X

X

X

X

X

X

X

X

Delay discounting

X

X

Opioid Purchase Task

X

X

X

X

X

X

X

X

X

X

Perceived social support

X

X

Buprenorphine-naloxone prescribed dose

X

X

X

X

X

X

X

X

X

X

Buprenorphine-naloxone dose log

X

X

X

X

X

X

X

X

X