Can multisite clinical trial results change clinical practice? Use of long-acting injectable risperidone nationally in the Veterans Health Administration

Table 3 Proportion of patients prescribed LAI risperidone who switched to LAI paliperidone in the subsequent year

Index year	Prior year	Prescribed LAI risperidone in prior year	Prescribed LAI paliperidone in subsequent year	Switching over to paliperidone from risperidone (%)	OR (95% CI)	Risk ratio (subsequent year changes compared to 2009–2015 change)
2010	2009	4361	255	5.9^{^}	0.40 (0.34, 0.47)
2011*	2010	4344	578	13.3		2.28
2012	2011	4098	495	12.1	0.90 (0.79, 1.03)	2.06
2013	2012	3760	370	9.8^{^,#}	0.73 (0.63, 0.83)	1.68
2014	2013	3601	384	10.7^{^}	0.80 (0.70, 0.92)	1.82
2015	2014	3223	403	12.5	0.97 (0.84, 1.11)	2.14

^*Used as the reference year to define pre- and post-publication of a cooperative study (CSP#555)
^{^}Statistically significant difference as compared to the reference year
^#Statistically significant difference when compared to the previous year (excluding comparisons with the reference year)

ISSN: 1745-6215