Table 1 Outcome measures
Outcome | Timepoint |
|---|---|
Incremental Shuttle Walking Test (ISWT) | Primary |
Short Physical Performance Battery (SPPB) | Secondary |
Quadriceps Maximal Voluntary Contraction (QMVC) | Secondary |
Handgrip strength | Secondary |
Physical activity | Secondary |
EuroQol 5 domain 5 level (EQ5D-5L) | Secondary |
Patient Health Questionnaire (PHQ-9) | Secondary |
Generalised Anxiety Disorder (GAD-7) | Secondary |
Dyspnoea 12 (D12) | Secondary |
SARC-F | Secondary |
Modified Medical Research Council (MRC) dyspnoea scale | Secondary |
Functional Assessment of Chronic Illness Therapy- Fatigue Scale (FACIT-FS) | Secondary |
General Practice Physical Activity Questionnaire (GPPAQ) | Secondary |
Nottingham Extended Activities of Daily Living (NEADL) | Secondary |
Depauls Symptom Questionnaire (DSQ) | Secondary |
Montreal Cognitive Assessment (MoCA) | Secondary |
Nijmegen questionnaire | Secondary |
Blood markers | Exploratory—optional |
Muscle biopsies | Exploratory—optional |