Implementation challenges and lessons learned from the STREAM clinical trial—a survey of trial sites

Table 4 Responses categorized into cross-cutting themes for challenges and best practices/lessons learned, by aspect of trial implementation^a

	Trial administration	Community engagement	Laboratory strengthening/infrastructure	Pharmacy and supply chain management	Regulatory requirements and ethics committee approvals	Health economics	Other^b
Cross-cutting challenge	Number of responses reporting the challenge under each aspect of trial implementation
Limited experience and capacity to undertake clinical trials	5	4	1	1	2	1	2
Underdeveloped infrastructure and/or inefficient processes	4	1	12	9	5	1	3
Limited communication/coordination and need for clear roles and responsibilities	8	2		1
Cross-cutting lesson learned/best practice	Number of responses reporting the best practice/lesson learned under each aspect of trial implementation
Sufficient training, capacity building, and supportive supervision	4	5	5	1	3	1	1
Sufficient infrastructure and/or streamlined processes	2		3	3			2
Good communication/coordination and clear roles and responsibilities	6	1	2	3	4		1

^aThe denominator for the number of responses for each aspect of clinical trial implementation varies and is a subset of the 47 total responses. Participants were asked to select all aspects of trial implementation for which a guidebook on lessons learned/best practices they thought would be the most beneficial for trial sites. For each aspect selected, they were then asked to list up to three challenges and best practices/lessons learned but not every respondent listed challenges and/or best practices/lessons learned. Responses were categorized by theme, and the table captures the number of responses that fit within the three cross-cutting themes
^bRespondent designated

ISSN: 1745-6215