Fig. 1From: Esketamine-based opioid-free anaesthesia alleviates postoperative nausea and vomiting in patients who underwent laparoscopic surgery: study protocol for a randomized, double-blinded, multicentre trialSchedule of enrolment, intervention and assessment according to the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement. Time points for implement of the study: t−1: when enrolled, t0: allocation, t1: before anaesthesia, t2: TCI propofol reached equilibrium, t3: in 3 min after sufentanil or esketamine infusion, t4: immediately after intubation, t5: in 5 min after intubation, t6: pneumoperitoneum, t7−x in each 15 min till the end of the surgery; ta−g refers to 0, 2, 4, 8, 24, 48 and 72 h after anaesthesiaBack to article page