Table 3 Median notional costs in GBP Sterling (£) of primary, secondary and total data collection costs for phase III, core outcome set and public health trials, including number of included phase III, core outcome and public health trials, together with the total number of data points included in our calculations for both primary, secondary, and all outcomes, the interquartile ranges including upper and lower limits. Note: two trials did not contribute to the ratio calculations (one phase III, one core outcome set) because the primary outcome Time to collect was 0 for both (i.e. including these led to a division by zero error)
Number of trials | Number of data points included | Median notional cost for total primary outcome collection [min–max] | IQR notional cost for total primary outcome collection [lower limit–upper limit] | Median notional cost for total secondary outcome collection [min–max] | IQR notional cost for total secondary outcome collection [lower limit–upper | Median notional total cost for total data collection [min–max] | IQR notional cost for total data collection [lower limit–upper | |
|---|---|---|---|---|---|---|---|---|
All included trials with full Time to collect data | 134 | 134 | £1319.50 [£0–£252,654.13] | £5307.09 [£4525.09–£14,049.72] | £4482.57 [£0–£31,899,140.70] | £14,329.35 [£12,566.10–£37,586.61] | £8015.73 [£52.90–£31,899,140.70] | £20,096.64 [£17,091.62–£53,246.62] |
Phase III | 100 | 100 | £1263.66 [£0–£252,654.13] | £3010.85 [£2242.36–£8295.60] | £3912.06 [£0–£31,899,140.70] | £11,430.02 [£9696.16–£30,308.92] | £7096.30 [£122.25–£31,899,140.70] | £16,581.51[£13,832.45–£44.202.82] |
Core outcome set | 17 | 17 | £979.58 [£0–£47,131.67] | £4073.11 [£3660.51–£10,595.37] | £3712.62 [£35.27–£29,622.60] | £7449.93 [£6108.09–£19,966.65] | £8901.67 [£52.90–£48,295.42] | £21,119.82 [£19,362.44–£54,556.91] |
Public health | 17 | 17 | £8319.21 [£160.65–£142,301.33] | £17,599.59 [£15,831.05–£45,767.50] | £11,852.96 [£213.94–£176,995.04] | £38,481.17 [£33,786.22–£100,897.87] | £20,043.45 [£427.88–£252,850.05] | £36,841.15 [£17,207.36–£111,736.67] |