Efficacy and safety of remimazolam for non-obese patients during anesthetic induction in cardiac surgery: study protocol for a multicenter randomized trial

Table 1 The SPIRIT figure of this trial

	Study period
	Enrollment	Allocation	Intervention	Post-intervention
Time point	Preoperative visit	Allocation	During induction until 20 min after induction	POD1	POD2	POD3	POD4	POD5	POD6	POD7
Enrollment
Eligibility screen	×
Informed consent	×
Demographic date	×
Allocation		×
Interventions
Midazolam			×
Etomidate			×
Remimazolam			×
Surgery and anesthesia date			×
Assessments			×
BIS			×
SBP/DBP/MBP HR/CVP/CO/SVR			×
RASS			×	×	×	×	×	×	×	×
CAM-ICU			×	×	×	×	×	×	×	×

POD postoperative day, BIS bispectral index, SBP systolic blood pressure, DBP diastolic blood pressure, MBP mean blood pressure, HR heart rate, CVP central venous pressure, CO cardiac output, SVR systematic vascular resistance, RASS Richmond Agitation-Sedation Scale, CAM-ICU Confusion Assessment Method in the intensive care unit

ISSN: 1745-6215