Inclusion criteria | Exclusion criteria |
---|---|
Age ≥18 years | Other inflammatory diseases, including: • rheumatoid arthritis • axial spondyloarthritis • systemic lupus erythematosus • Lyme disease |
Active PsA despite previous csDMARD, NSAID, and/or apremilast, and/or NSAID therapy | |
Diagnosis of PsA for ≥6 months prior to first administration of study intervention and meeting CASPAR criteria at screening | Previous biologic therapy for PsA or psoriasis |
Prior therapy with systemic immunosuppressants or apremilast within 4 weeks of study agent administration | |
Active PsA: • ≥3 swollen joints • ≥3 tender joints • CRP ≥0.3 mg/dL | Currently receiving ≥3 csDMARDs |
≥2 joints with erosions on baseline radiographs of the hands and feet as determined by central read (2 readers and adjudicator if needed) | |
≥1 of the following PsA subtypes: • distal interphalangeal joint involvement • polyarticular arthritis with absence of rheumatoid nodules • asymmetric peripheral arthritis • spondylitis with peripheral arthritis | |
Active plaque psoriasis (≥1 plaque of ≥2 cm diameter and/or psoriatic nail changes) |