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Table 2 Pre-determined stopping rules

From: Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial

Analysis

% of events

Futility

Superiority

Z

Beta-spend

Z

Alpha-spend

I

57%

0.36

0.0370

2.60

0.0046

II

100%

1.99

0.1630

1.99

0.0204

Total

 

0.20

 

0.025

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Trials

ISSN: 1745-6215