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Table 1 Characteristics of included funding applications

From: Inclusion of progression criteria in external randomised pilot trials: a cross-sectional study of funding applications submitted to the NIHR Research for Patient Benefit Programme

 

Outline application

(Stage 1)

(n = 95)

Full application

(Stage 2)

(n = 49)

Therapeutic areasa

 Oncology

12 (13%)

5 (10%)

 Psychiatry/Ppychology

12 (13%)

7 (14%)

 Paediatrics

10 (11%)

7 (14%)

 Respiratory

7 (7%)

4 (8%)

 Primary care

7 (7%)

1 (2%)

 Gastroenterology/hepatology

6 (6%)

3 (6%)

 Trauma

5 (5%)

4 (8%)

 Other

36 (38%)

18 (37%)

Intervention type

 Drug

9 (9%)

4 (8%)

 Surgery or procedure

15 (16%)

8 (16%)

 Counselling, lifestyle or physiotherapy

55 (58%)

28 (57%)

 Equipment

4 (4%)

3 (6%)

 Medical device

1 (1%)

1 (2%)

 Other

11 (12%)

5 (10%)

Randomisation design

 Parallel

84 (88%)

45 (92%)

 Parallel + patient preference arms

2 (2%)

0 (0%)

 Cluster

9 (9%)

4 (8%)

Sample size

 Sample size unclear in funding application

4

0

 Min-max

20-250

25-800

 Median

60

60

 IQR

50-90

50-80

Single/multi-centre

 Single

19 (20%)

10 (20%)

 Multi

69 (73%)

36 (73%)

 Unclear

7 (7%)

3 (6%)

Number of arms

 2

84 (88%)

44 (90%)

 >2

11 (12%)

5 (10%)

Primary focus is the assessment of feasibility

 Yes

94 (99%)

49 (100%)

 Nob

1 (1%)

0 (0%)

Qualitative research conducted

 Yes

80 (84%)

44 (90%)

 No

15 (16%)

5 (10%)

  1. Percentages might not add up to 100 due to rounding
  2. 95 Stage 1 applications were included, 52 were invited to Stage 2, three were ineligible and 49 were included
  3. aTherapeutic areas that were given in ≥5 Stage 1 application outlines are listed; all others are categorised in ‘other’
  4. bThe primary focus of one study was only on safety rather than feasibility, this study was redesigned at Stage 2 as single arm proof of concept study (ineligible at Stage 2)