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Table 4 Subgroup analyses overview

From: Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): protocol for a randomized controlled trial

Objective

Outcome

Hypothesis

Method of analysis

Name

Type

Subgroup Analysis 1

 Males versus females

PPSP as defined by the WHO, and of ≥ 4/10 severity

Binary

CBT will be associated with a larger reduction in the prevalence of PPSP in females compared to males

Logistic regression

Subgroup Analysis 2

 Any open fracture versus no open fracture

PPSP as defined by the WHO, and of ≥ 4/10 severity

Binary

CBT will be associated with a larger reduction in the prevalence of PPSP in participants with open fractures compared to participants with only closed fractures

Logistic regression

Subgroup Analysis 3

 Military, veteran, and first responders versus other patients

PPSP as defined by the WHO, and of ≥ 4/10 severity

Binary

CBT will be associated with a larger reduction in the prevalence of PPSP in participants who are employed by the military, veterans, or first responders

Logistic regression

Subgroup Analysis 4

 Higher versus lower SPOC scores

PPSP as defined by the WHO, and of ≥ 4/10 severity

Binary

CBT will be associated with a larger reduction in the prevalence of PPSP in participants with higher vs. lower SPOC scores

Logistic regression

  1. PPSP Persistent post-surgical pain