Table 2 Sample size per arm (80% study power, alpha = 0.05). Difference in the proportion of persistent post-surgical pain, between treatment and control groups
Relative risk reduction in moderate to severe persistent pain | ||||
|---|---|---|---|---|
15% | 20% | 25% | ||
Proportion of moderate to severe persistent pain in control group (p1) | 40% | 1049 | 589 | 376 |
45% | 866 | 488 | 313 | |
50% | 719 | 408 | 262 | |
55% | 600 | 342 | 221 | |