The SCRIPT trial: study protocol for a randomised controlled trial of a polygenic risk score to tailor colorectal cancer screening in primary care

Table 1 SCRIPT trial participant timeline

	Trial period
	Enrolment	Allocation to intervention		Post-allocation^a
Time point	0	0	*2–3 weeks*	*1 month*	*6 months*	*12 months*	*5 years*
Enrolment
Eligibility screen	X
Informed consent	X
Allocation to intervention		X
Interventions
*SCRIPT intervention*			X (PRS report)
*Control*		X (cancer risk reduction brochure)				X (PRS report)
Assessments
*Demographics*	X
*CRC screening + health service utilisation data (GP record, MBS, NBCSP, VAED)*						X	X
*CRC screening data (participant report)*	X			X	X	X
*CRC risk perception*	X			X	X	X
*Cancer-specific anxiety (Cancer Worry Scale)*	X			X	X	X
*Influences of CRC screening behaviour (Preventative Health Model)*	X			X	X	X
*Cancer screening intentions*	X			X	X	X

^aFor the intervention arm, time points are after provision of PRS report and for the control arm, after standard cancer risk reduction information (i.e. last information regarding CRC risk and screening information)

ISSN: 1745-6215