Inhaled aviptadil for the possible treatment of COVID-19 in patients at high risk for ARDS: study protocol for a randomized, placebo-controlled, and multicenter trial

Table 1 WHO-Ordinal scale for clinical improvement

Patient state	Descriptor	Score
*Uninfected*	No clinical or virological evidence of infection	0
*Ambulatory*	No limitation of activities	1
*Ambulatory*	Limitation of activities	2
*Hospitalized: mild disease*	Hospitalized, no oxygen therapy	3
*Hospitalized: mild disease*	Oxygen by mask or nasal prongs	4
*Hospitalized: severe disease*	Non-invasive ventilation or high-flow oxygen	5
	Intubation and mechanical ventilation	6
	Ventilation + additional organ support – pressors, RRT, ECMO	7
*Dead*	Death	8

From: WHO R&D Blueprint, Novel Coronavirus COVID-19 Therapeutic Trial Synopsis [55]
RRT renal replacement therapy, ECMO extracorporeal membrane oxygenation

ISSN: 1745-6215