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Table 2 Magnetic resonance imaging sequences and parameters at the four study sites

From: Study protocol for a randomised controlled trial of diacerein versus placebo to treat knee osteoarthritis with effusion-synovitis (DICKENS)

 

Machine and coils

T2-weighted sagittal 3D

T1-weighted sagittal 3D

Hobart

1.5 T whole-body MR unit (GE Optima 450W, Milwaukee, USA), using a dedicated Transmit/Receive 8-channel knee coil where patient size permits, if body habitus is too large, we use a 16-channel large GEM Flex coil

T2 weighted fat-saturated 3D fast spin echo sequence; flip angle 90°, repetition time 2300 ms; echo time 95 ms; field of view 18 cm; 256 × 256 matrix; 2 excitations; slice thickness 1 mm

T1-weighted fat-saturated 3D gradient recalled acquisition; flip angle 30°; repetition time 38 ms; echo time 3 ms; field of view 16 cm; 256 × 256 matrix; 1 excitation; slice thickness 1.5 mm

Melbourne

3 T whole-body MR unit (Siemens, Magnetom Avanto Fit, Erlangen, Germany), using a dedicated Transmit/Receive 15 channel knee coil

T2 weighted fat-saturated 3D fast spin echo sequence; flip angle 120°; repetition time 1200 ms; echo time 50 ms; field of view 16 cm; 256 × 320 matrix; 1 excitation; slice thickness 0.6 mm

T1-weighted fat-saturated 3D gradient recalled acquisition; flip angle 30°; repetition time 11.7 ms; echo time 5.61 ms; field of view 16 cm; 320 × 320 matrix; 1 excitation; slice thickness 1.5 mm

Perth

1.5 T whole-body MR unit (Siemens, Magnetom Avanto Fit, Erlangen, Germany), using a dedicated Transmit/Receive 15 channel knee coil

T2 weighted fat-saturated 3D fast spin echo sequence; flip angle 90°; repetition time 2302 ms; echo time 81 ms; field of view 18 cm; 256 × 256 matrix; 2 excitations; slice thickness 1 mm

T1-weighted fat-saturated 3D gradient recalled acquisition; flip angle 30°; repetition time 17.7 ms; echo time 3.5 ms; field of view 18 cm; 256 × 160 matrix; 1 excitation; slice thickness 1.4 mm

Adelaide

3 T whole-body MR unit (Siemens, Magnetom Skyra 3Tesla), using a dedicated 15-channel knee coil

T2 weighted fat-saturated 3D SPACE; flip angle 120°; repetition time 2200 ms; echo time 121 ms; field of view 16 cm; 320 × 259 matrix; 1 excitation; slice thickness 0.6 mm

T1-weighted Water Excitation 3D gradient recalled acquisition VIBE; flip angle 16°; repetition time 10.4 ms; echo time 5.7 ms; field of view 160 cm; 320 × 320 matrix; 1 excitation; slice thickness 1 mm

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Trials

ISSN: 1745-6215