Optimising recruitment in clinical trials for progressive multiple sclerosis: observational analysis from the MS-SMART and MS-STAT2 randomised controlled trials

Table 2 Comparison of recruitment efficiency between MS-SMART and MS-STAT2

	MS-SMART	MS-STAT2
Eligible at online portal self-screening questionnaire (UK-wide)	NA	1525/4605 (33%)
Successful contact^a	824/1000 (82%)	941/1150 (82%)
Eligible after telephone pre-screening^b	319/824 (39%)	374/941 (40%)
Pre-screened patients who attended face-to-face screening (%)^c	237/319 (75%)	350/374 (94%)
Eligible at face-to-face screening^d	195/237 (82%)	312/350 (89%)
Total randomised as % of all potential participants manually considered	176/1000 (18%)	315/1150 (27%)
Total randomised as % of those passing pre-screening	176/319 (55%)	315/374 (84%)
Total randomised as % of those who attended screening^d	176/237 (74%)	315/350 (90%)

Data on the pass rate for the online portal questionnaire for MS-STAT2 are for UK-wide responses; all subsequent data are for the UCL sites only. NA, not applicable (as the MS-SMART online portal did not include a self-screening questionnaire)
^aThose successfully contacted as a percentage of all potential participants manually considered
^bThose eligible at telephone pre-screening as a percentage of those successfully contacted
^cThose who attended a face to face screening appointment, as a percentage of those deemed potentially eligible at telephone pre-screening and invited to attend screening
^dThose eligible at screening as a percentage of those attending screening, and total randomised as a percentage of those attending screening, produce different figures due to some patients who are eligible at screening not proceeding to randomisation, and some initially ineligible patients being rescreened if the eligibility issue could be resolved

ISSN: 1745-6215