Table 2 Trial descriptive and recruitment information by year started
From: Update on the clinical trial landscape: analysis of ClinicalTrials.gov registration data, 2000–2020
A: Counts (n) by year started | ||||||||||||
Year started | Trials started | Sponsor | Has DSMC | Protocol included | Sex | Age | ||||||
N | Industry | NIH/US Gov | Other | Yes | Yes | Men only | Women only | All | Adults only | Children only | Adults and children | |
2000 | 1873 | 456 | 323 | 1094 | 373 | 6 | 87 | 224 | 1552 | 248 | 113 | 1512 |
2001 | 2399 | 746 | 359 | 1294 | 432 | 3 | 125 | 286 | 1974 | 363 | 129 | 1907 |
2002 | 3492 | 1336 | 427 | 1729 | 683 | 11 | 173 | 376 | 2935 | 558 | 217 | 2717 |
2003 | 4765 | 1773 | 420 | 2572 | 1040 | 15 | 254 | 490 | 4012 | 817 | 292 | 3656 |
2004 | 6314 | 2380 | 549 | 3385 | 1433 | 36 | 322 | 651 | 5331 | 1016 | 380 | 4918 |
2005 | 7728 | 2832 | 499 | 4397 | 1973 | 55 | 388 | 707 | 6624 | 1259 | 489 | 5980 |
2006 | 9297 | 3558 | 523 | 5216 | 2748 | 67 | 474 | 863 | 7950 | 1630 | 581 | 7086 |
2007 | 10,412 | 3940 | 415 | 6057 | 3714 | 62 | 531 | 992 | 8883 | 1911 | 622 | 7879 |
2008 | 11,874 | 4364 | 399 | 7111 | 4239 | 105 | 652 | 1143 | 10,066 | 2244 | 689 | 8941 |
2009 | 12,825 | 4379 | 402 | 8044 | 4794 | 177 | 729 | 1156 | 10,928 | 2473 | 787 | 9565 |
2010 | 13,402 | 4289 | 459 | 8654 | 5093 | 211 | 732 | 1221 | 11,441 | 2619 | 814 | 9969 |
2011 | 14,175 | 4420 | 411 | 9344 | 5391 | 334 | 831 | 1304 | 12,024 | 2877 | 919 | 10,379 |
2012 | 14,995 | 4271 | 344 | 10,380 | 5914 | 554 | 847 | 1454 | 12,683 | 3069 | 973 | 10,953 |
2013 | 15,829 | 4223 | 352 | 11,254 | 6141 | 940 | 909 | 1438 | 13,471 | 3279 | 998 | 11,552 |
2014 | 17,508 | 4581 | 350 | 12,577 | 6545 | 1391 | 985 | 1684 | 14,822 | 3682 | 1110 | 12,716 |
2015 | 18,807 | 4621 | 378 | 13,808 | 6844 | 2268 | 967 | 2003 | 15,814 | 3890 | 1157 | 13,760 |
2016 | 20,168 | 4586 | 370 | 15,212 | 7096 | 3013 | 994 | 2107 | 17,044 | 4097 | 1317 | 14,754 |
2017 | 20,917 | 4529 | 354 | 16,034 | 7263 | 3310 | 1006 | 2163 | 17,739 | 4248 | 1338 | 15,331 |
2018 | 22,285 | 4875 | 374 | 17,036 | 7170 | 2814 | 983 | 2243 | 19,042 | 4416 | 1429 | 16,440 |
2019 | 22,847 | 4832 | 377 | 17,638 | 7370 | 1699 | 995 | 2241 | 19,602 | 4441 | 1378 | 17,028 |
2020 | 22,131 | 4918 | 270 | 16,943 | 7565 | 835 | 859 | 1958 | 19,306 | 4038 | 1159 | 16,934 |
Total | 274,043 | 75,909 | 8355 | 189,779 | 93,821 | 17,906 | 13,843 | 26,704 | 233,243 | 53,175 | 16,891 | 203,977 |
B: Percent (%) by year | ||||||||||||
Sponsor | Has DSMC | Protocol included | Eligibility: sexa, b | Eligibility: age (%) | ||||||||
Year started | Industry | NIH/US Gov | Other | Yes (%) | Yes (%) | Men only (%) | Women only (%) | All (%) | Adults only (%) | Children only (%) | Adults and children | |
2000 | 24.3 | 17.2 | 58.4 | 19.9 | 0.3 | 4.6 | 12.0 | 82.9 | 13.2 | 6.0 | 80.7 | |
2001 | 31.1 | 15.0 | 53.9 | 18 | 0.1 | 5.2 | 11.9 | 82.3 | 15.1 | 5.4 | 79.5 | |
2002 | 38.3 | 12.2 | 49.5 | 19.6 | 0.3 | 5.0 | 10.8 | 84.0 | 16.0 | 6.2 | 77.8 | |
2003 | 37.2 | 8.8 | 54.0 | 21.8 | 0.3 | 5.3 | 10.3 | 84.2 | 17.1 | 6.1 | 76.7 | |
2004 | 37.7 | 8.7 | 53.6 | 22.7 | 0.6 | 5.1 | 10.3 | 84.4 | 16.1 | 6.0 | 77.9 | |
2005 | 36.6 | 6.5 | 56.9 | 25.5 | 0.7 | 5.0 | 9.1 | 85.7 | 16.3 | 6.3 | 77.4 | |
2006 | 38.3 | 5.6 | 56.1 | 29.6 | 0.7 | 5.1 | 9.3 | 85.5 | 17.5 | 6.2 | 76.2 | |
2007 | 37.8 | 4.0 | 58.2 | 35.7 | 0.6 | 5.1 | 9.5 | 85.3 | 18.4 | 6.0 | 75.7 | |
2008 | 36.8 | 3.4 | 59.9 | 35.7 | 0.9 | 5.5 | 9.6 | 84.8 | 18.9 | 5.8 | 75.3 | |
2009 | 34.1 | 3.1 | 62.7 | 37.4 | 1.4 | 5.7 | 9.0 | 85.2 | 19.3 | 6.1 | 74.6 | |
2010 | 32.0 | 3.4 | 64.6 | 38.0 | 1.6 | 5.5 | 9.1 | 85.4 | 19.5 | 6.1 | 74.4 | |
2011 | 31.2 | 2.9 | 65.9 | 38.0 | 2.4 | 5.9 | 9.2 | 84.8 | 20.3 | 6.5 | 73.2 | |
2012 | 28.5 | 2.3 | 69.2 | 39.4 | 3.7 | 5.6 | 9.7 | 84.6 | 20.5 | 6.5 | 73.0 | |
2013 | 26.7 | 2.2 | 71.1 | 38.8 | 5.9 | 5.7 | 9.1 | 85.1 | 20.7 | 6.3 | 73.0 | |
2014 | 26.2 | 2.0 | 71.8 | 37.4 | 7.9 | 5.6 | 9.6 | 84.7 | 21.0 | 6.3 | 72.6 | |
2015 | 24.6 | 2.0 | 73.4 | 36.4 | 12.1 | 5.1 | 10.7 | 84.1 | 20.7 | 6.2 | 73.2 | |
2016 | 22.7 | 1.8 | 75.4 | 35.2 | 14.9 | 4.9 | 10.4 | 84.5 | 20.3 | 6.5 | 73.2 | |
2017 | 21.7 | 1.7 | 76.7 | 34.7 | 15.8 | 4.8 | 10.3 | 84.8 | 20.3 | 6.4 | 73.3 | |
2018 | 21.9 | 1.7 | 76.4 | 32.2 | 12.6 | 4.4 | 10.1 | 85.4 | 19.8 | 6.4 | 73.8 | |
2019 | 21.1 | 1.7 | 77.2 | 32.3 | 7.4 | 4.4 | 9.8 | 85.8 | 19.4 | 6.0 | 74.5 | |
2020 | 22.2 | 1.2 | 76.6 | 34.2 | 3.8 | 3.9 | 8.8 | 87.2 | 18.2 | 5.2 | 76.5 | |
Average | 30.0 | 5.1 | 64.8 | 31.5 | 4.5 | 5.1 | 9.9 | 84.8 | 18.5 | 6.1 | 75.4 | |