Table 1 Treatment groups
From: Ketamine for acute pain after trauma: the KAPT randomized controlled trial
Group | Ketamine Infusion Group | Usual Care |
|---|---|---|
Drug dose | Bolus: 0.35 mg/kg Infusion: start 0.15 mg/kg/hr; titration range is 0.1–0.25 mg/kg/hr | None |
Duration | 24 (minimum) to 72 (maximum) hours after admission and each subsequent major surgery | n/a |
Usual Care | • Acetaminophen 1,000 mg PO q6 hours • Naproxen 500 mg PO q12 hours • Gabapentin 300 mg PO q8 hours • Lidocaine patches Opioids as needed for additional pain control | • Acetaminophen 1,000 mg PO q6 hours • Naproxen 500 mg PO q12 hours • Gabapentin 300 mg PO q8 hours • Lidocaine patches Opioids as needed for additional pain control |
Timing | Ketamine drip to begin as early as possible: • Hemodynamically stable patients – start immediately (ideally in ED prior to CT scan) • Hemodynamically unstable patients – start once stabilized |