Table 1 Schedule of enrolment, interventions, and assessments

Timepoint

0

0

2 h

12 h

1–28 days maximum

28 days maximum

 Eligibility screen

×

 Informed consent

×

 Allocation

×

Interventions

 NIV

 HFNC

 Baseline variables

  Demographics

×

  Medical history

×

  Mechanism of injury

×

  Injury severe score

×

  Chest AIS score

×

  SOFA score

×

 Outcome variables

  Intubation

×

×

×

  Treatment switch

×

×

×

  Vital signs

×

×

×

×

  Comfort score

×

×

×

×

  Dyspnea score

×

×

×

×

  Arterial blood gas

×

×

×

×

  Number of nursing airway care interventions

×

  Pneumonia or pneumothorax

×

  Skin breakdown

×

  Causes of treatment failure

×

  NIV/HFNC duration

×

  Hospital length of stay

×

  ICU length of stay

×

  28-day mortality

×