Table 1 Example template of recommended content for the schedule of enrollment, interventions, and assessments

 Screening

X

 Informed consent

X

 Cohort 1 (ATO + P)

X

X

X

X

X

X

 Cohort 1 (T + P)

X

X

X

X

X

X

 Patients characteristic

X

 Medical history

X

 Performance status

X

 Karnofsky

X

 Blood test

X

X

X

X

X

 Liver function test

X

X

X

X

X

 Kidney function test

X

X

X

X

X

 Color Doppler ultrasound

X

X

X

 Tumor markers

X

X

X

 Imaging examination (MRI)

X

X

 RECIST

X

 CTCAE

X

Cohort migration

X

Combined medication

X