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Table 3 List of possible effects due to rifampicin, clarithromycin, and amoxicillin/clavulanate

From: Comparison of 8 weeks standard treatment (rifampicin plus clarithromycin) vs. 4 weeks standard plus amoxicillin/clavulanate treatment [RC8 vs. RCA4] to shorten Buruli ulcer disease therapy (the BLMs4BU trial): study protocol for a randomized controlled multi-centre trial in Benin

 

Rifampicin

Clarithromycin

Amoxicillin/clavulanate

More common

None

None

Nausea, vomiting, headache, diarrhoea, gas, stomach pain, skin rash or itching, white patches in your mouth or throat

Less common/rare

Chills, difficult breathing, dizziness, fever, headache, itching, muscle and bone pain, shivering, skin rash and redness; bloody or cloudy urine, increased frequency of urination or amount of urine, loss of appetite, nausea or vomiting, sore throat, unusual bleeding or bruising, unusual tiredness or weakness, yellow eyes or skin

Loss of appetite, nausea, dyspepsia; changes in taste and smell sensation; headache; ringing or buzzing in the ears (tinnitus), dizziness; liver enzyme elevation; allergic skin reactions including Stevens-Johnson syndrome; blood dyscrasias; reversible loss of hearing

Watery or bloody diarrhoea; pale or yellowed skin, dark coloured urine, crystalluria, fever, confusion or weakness; easy bruising or bleeding; skin rash, bruising, severe tingling, numbness, pain, muscle weakness; agitation, confusion, unusual thoughts or behaviour, seizures (convulsions); nausea, upper stomach pain, itching, loss of appetite, clay-coloured stools, jaundice (yellowing of the skin or eyes), or severe skin reaction; sore throat, swelling in face or tongue, burning in eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling