The Appalachia Mind Health Initiative (AMHI): a pragmatic randomized clinical trial of adjunctive internet-based cognitive behavior therapy for treating major depressive disorder among primary care patients

Table 6 Self-report questionnaire (SRQ) outcomes

	Assessment timepoints
	2 weeks	4 weeks	8 weeks	13 weeks	16 weeks	26 weeks	39 weeks	52 weeks
Primary outcome
Dichotomous definition of remission from depression^a					X	X	X	X
Secondary outcomes
Dimensional remission from depression scores^a					X	X	X	X
Substance use disorder symptoms^b					X	X	X	X
Treatment compliance^c	X	X	X	X	X	X	X	X
Treatment engagement^d	X	X	X	X	X	X	X	X
Shared decision making^e								X
Perception of recovery/remission^f	X	X	X	X	X	X	X	X
Treatment satisfaction^f	X	X	X	X	X	X	X	X
Other measures
Current stressors^g	X	X	X	X	X	X	X	X
Current treatment^h	X	X	X	X	X	X	X	X
Medication side effectsⁱ	X	X	X	X	X	X	X	X

^aOperationalized with questions from the Remission from Depression Questionnaire (RDQ) [64], 16-Item Quick Inventory of Depressive Symptomatology Self-Report Scale (QIDS-SR) [89], full Inventory of Depressive Symptomatology Self-Report Scale (IDS-SR) [90], Composite International Diagnostic Interview (CIDI) [94], DSM-5 Anxious Distress Specifier and Melancholic Features Specifier for Depressive Disorders [91], and the Sheehan Disability Scale (SDS) [118]
^bThe 7-question PROMIS Alcohol/Substance Use Short Form - 7a scale [87, 106]
^cAdapted two questions from the Brief Adherence Rating Scale (BARS) [177] to assess medication and psychotherapy treatment compliance [78]
^di-CBT engagement will be monitored by analyzing SilverCloud meta-data
^eThe 3-item CollaboRATE scale [79]
^fCreated questions to measure patient perceived remission [178, 179]; and treatment satisfaction [180]
^gQuestions taken from Army STARRS Survey [98]
^hItems developed for AMHI Study
ⁱThe Frequency, Intensity, and Burden of Side Effects Ratings (FISBER) scale [174]

ISSN: 1745-6215