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Table 5 Detailed timetable of procedures and assessments in periods 1, 2, 3, and 4

From: IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

  1. aThe PK sample on next day can be taken at any suitable time provided that the exact time of sampling is precisely recorded
  2. bHyperalgesia testing at the sensitized and contralateral size, harmonized across all four IMI2-PainCare-BioPain RCTs
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Trials

ISSN: 1745-6215