Evolocumab administration prior to Coronary Artery Bypass Grafting in patients with multivessel coronary artery disease (EVOCABG): study protocol for a randomized controlled clinical trial

Table 1 Participant timeline

	Study period
Visit description	Enrollment	Allocation	Intervention	Postoperation					Discharge	Close-out
Visit number	V1			V2	V3	V4	V5	V6	V7	V8
Timepoint	− 72h~0			0h±2h	6h±2h	24h±6h	48h±6h	72h±6h	7 days ± 3 days	30 days ± 5 days
Enrollment:
Eligibility screen	X
Informed consent	X
Allocation		X
Intervention:
Evolocumab administration			X
No medication			X
Assessment:
Demographics	X
Medical history	X
Vital signs, physical data^a	X			X	X	X	X	X	X	X
Urine HCG	X
ECG^b	X			X		X	X	X
Laboratory tests	X			X	X	X	X	X	X
Concomitant drug	X			X	X	X	X	X	X	X
Outcome variables^c	X			X	X	X	X	X	X
Transthoracic echocardiography	X							X
Clinical results^d, safety evaluation			X	X	X	X	X	X	X	X

HCG human chorionic gonadotropin, ECG electrocardiogram
^aPhysical data include height and body weight
^bECG can be additionally performed at the discretion of the physicians
^cOutcomes variables include primary outcomes such as cardiac enzymes
^dClinical results include data on death, recurrent myocardial infarction, heart failure, stroke, new-onset atrial fibrillation, and prolonged hospitalization

ISSN: 1745-6215