Safety parameters | Efficacy parameters | Other variables |
---|---|---|
Renal function • Serum creatinine and method of determination (colorimetric or enzymatic) • Cystatin-C • Serum creatinine-based eGFR • Cystatin-C-based eGFRa • Cystatin-C-based mean eGFR (calculated from the highest cystatin-C level during day 1-3)a • AKIN scoreb • RIFLE stageb • Urine output (if available) Coagulation • Platelet count • International normalized ratio • Activated partial thromboplastin time Inflammation • C-reactive protein Adverse events • (Serious) adverse events/reactions Outcome • Length of stay (LOS): □ LOS in the hospital □ LOS in the intensive care unitc □ Fulfilment of fit for discharge from ICU/hospitald • Hours on mechanical ventilation • In-hospital/out of hospital mortality (incl. cause) • Days on renal replacement therapy | Fluid administration • Administration of IP volume Fluid balance • Fluid input and output Hemodynamics/vital signs • Heart rate • Mean arterial pressure (MAP) • Systolic arterial blood pressure • Diastolic arterial blood pressure • Central venous pressurec at least one of the following parameters (volume algorithm): • Stroke volume (SV) • Stroke volume variation (SVV) • Stroke volume index (SVI) • Pulse pressure variation (PPV) • Mean arterial blood pressure (MAP) Laboratory data • Arterial (preferred) blood gas analysis □ Partial pressure of carbon dioxide □ Partial pressure of oxygen □ Bicarbonate □ Arterial oxygen saturation □ pH □ Base excess □ Lactate □ Hemoglobin □ Hematocrit Central venous oxygen saturationc • Serum electrolytes □ Sodium □ Potassium □ Calcium □ Chloride | Demographic data and medical history • Age • Gender • Height • Weight • Ethnicity • Anamnesis and concomitant diseases (only ongoing and relevant resolved) • Fluid input from trauma injury until hospital admission Trauma-related data • Blunt/penetrating trauma • Injury characteristics □ Injury Severity Score □ Glasgow Coma Scale Surgery due to traumatic injury □ Type of surgery Concomitant medication • Vasoactive/inotropic drugs • Amount of transfused blood products [19] including specification (if available) • Coagulation factors (i.e., fibrinogen/PCC/factor XIII) • Antibiotic therapy • Contrast agents • Diuretics • Crystalloid solutions/albumin (incl. basal infusion) |