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Table 4 Participant Timeline (group 4: treatment introduction at week 12)

From: Topical sirolimus solution for lingual microcystic lymphatic malformations in children and adults (TOPGUN): study protocol for a multicenter, randomized, assessor-blinded, controlled, stepped-wedge clinical trial

  1. a For women of childbearing potential, until 3 months after study close-up
  2. b Drug dispensation: 3 bottles for 8 weeks (8w) or 2 bottles for 4 weeks (4w)