Table 1 Characteristics of included studies
Bibliographic information | Country | Methodology | Surgical speciality/field | Participants/included studies |
|---|---|---|---|---|
Anderson et al. (2019) [33] | Australia | Semi-structured interviews | Lumbar decompression surgery | N=63 People diagnosed with central lumbar spinal canal stenosis considered suitable for lumbar decompression surgery |
Baldwin, Wartolowska and Carr (2016) [34] | UK | Online survey | Orthopaedic surgery | N= 189 Members of the British orthopaedic trainees association |
Campbell et al. (2010a) [35] | USA | Narrative review and case study | Orthopaedic/general surgery | Surgical RCTs and a case study of a paediatric orthopaedic RCT |
UK | Mixed methods/feasibility study (surveys, interviews, and focus groups) | Orthopaedic surgery | N=41 surgeons (three focus groups); N=130 orthopaedic anaesthetists (plenary discussion); N=58 anaesthetists (three focus groups); N=7 members of patient organisation Arthritis care (two focus groups); N=15 people on consultant waiting lists for treatment (telephone interviews); N=6 chairs of UK ethics committees (interviews); N=382 members of the British Association of Surgeons of the Knee (postal surveys); N=398 members of the British Society of Orthopaedic Anaesthetists (postal survey) N=49 patients (two centre pilot study) | |
Cook et al. (2009) [38] | UK | Narrative review | General surgery | Clinical trials conducted in surgery |
Frank et al. (2008) [39] | USA | Survey study | Neurosurgery (gene therapy via intracerebral delivery) | N=56 people with Parkinson’s disease; N=113 non-PD neurology patients; N=119 primary care patients |
Hare et al. (2014) [40] | Denmark | Randomised controlled trial (participation interview) | Orthopaedic surgery | N=40 people with referrals for suspected medial meniscus lesion |
Kim et al. (2012a) [41] | USA | Semi-structured interviews | Neurosurgery (cellular and gene transfer) | N=90 people who were participating in one of 3 sham-controlled intervention trials for Parkinson’s disease |
Kim et al. (2012b) [42] | USA | Semi-structured interviews | Neurosurgery (cellular and gene transfer) | N=71 61 enrolees and 10 decliners of participation in 2 invasive placebo surgery controlled randomised trials. |
Kim et al. (2013) [43] | USA | Semi-structured interview | Neurosurgery (gene therapy via intracerebral delivery) | N=29 People considering enrolment in an early-phase gene transfer trial for Parkinson’s disease |
Kim et al. (2015) [44] | USA | Semi-structured interviews | Neurosurgery (cellular and gene transfer) | N=90 people with advanced Parkinson’s disease enrolled or intending to enrol in one of 3 placebo-controlled neurosurgical trials |
Rios et al. (2021) [45] | USA | Summary and recommendations from a prematurely closed randomised placebo-controlled trial | Paediatric orthopaedic surgery | Discussion of a randomised, placebo-controlled trial of bone morphogenetic protein graft at the time of tibial surgery |
Swift (2012) [46] | UK | Semi-structured interviews | Gene therapy via intracerebral delivery | N=20 People with Parkinson’s disease considering enrolment in an early-phase gene transfer trial for Parkinson’s disease, and their family members, friends, or carers |
Tuszynski et al. (2007) [47] | USA | Guidelines for the conduct of spinal cord injury trials | Surgical interventions for spinal injury | Surgery trials for interventions including including decompression, targeted drug delivery, and spinal laminectomy |
Wartolowska, Beard and Carr (2014) [12] | UK | Online survey | Orthopaedic surgery | N=100 Orthopaedic shoulder surgeons |
Wiebe (2003) [48] | UK | Narrative review | Neurosurgery | RCTs of surgical interventions for epilepsy |
Wright et al. (2011) [49] | USA and Canada | Outcomes of the Clinical Trials in Orthopaedics Research Symposium | Orthopaedic surgery | RCTs in orthopaedics |