Table 2 Trial activity timeline

 Eligibility screen

x

 Informed consent

x

 Treatment allocation

x

 Midodrine or placebo

x

 Age, sex

x

 Weight and height

x

 Date of eligibility

x

 ICU and hospital admission date

x

 ICU admission type

x

 ICU admission diagnosis

x

 Clinical frailty scale score

x

 APACHE II score

x

 Etiology of shock

x

 Comorbid illness

x

 Vasopressor therapy

x

x

 Mechanical ventilation

x

x

 Total duration of vasopressor support

x

 Vasopressors initiated after cessation

x

 ICU or hospital death

x

 Date of ICU death or discharge

x

 ICU length of stay

x

 Hospital length of stay

x

 ICU readmission during hospital stay

x

 Discharge location from hospital

x

 Persistent organ dysfunction or death

x

x

 EQ-5D

x

Adverse events

x

x

x

x

x

 Cardiac events (clinically significant bradycardia, acute coronary syndrome)

x

x

x

x

x

 Allergic events (paresthesia, piloerection, dysuria, pruritis, chills, pain, rash)

x

x

x

x

x

 Hypertension

x

x

x

x

x

 Bowel ischemia

x

x

x

x

x

 Limb ischemia

x

x

x

x

x

 Stroke

x

x

x

x

x

 Protocol violations

x

x

x

x

x