Author | Year | Study type | Centre(s) | Number | Population | Intervention | Control | Primary outcome | Surrogate vs patient-centred | LFU (days) |
---|---|---|---|---|---|---|---|---|---|---|
Csontos et al. [71] | 2008 | RCT | 1 | 24 | TBSA > 15% | PICCO | Urine output | Central venous O2 saturations | Surrogate | 3 |
Holm et al [72] | 2004 | RCT | 1 | 50 | TBSA > 20% | Transpulmonary thermodilution method for CO | Baxter formula and urine output | In-hospital mortality | Patient-centred | > 25 |
Tokarik et al. [73] | 2013 | RCT | 1 | 21 | TBSA 10–75% with burn shock | LiDCO | Physician led resuscitation | Cumulative fluid balance | Surrogate | 37 |
Holm et al [74] | 2001 | CSWCC | 1 | 23 | ABSI ≥ 6 | Transpulmonary thermodilution for CO | Pulmonary artery catheter for CO | Cardiac output | Surrogate | 3 |