Table 3 Fluid resuscitation studies
Author | Year | Study type | Centre(s) | Number | Population | Intervention | Control | Primary outcome | Surrogate vs patient-centred | LFU (days) |
|---|---|---|---|---|---|---|---|---|---|---|
Bechir et al. [45] | 2013 | RCT | 1 | 48 | TBSA > 15% | Hydroxyethyl starch with RL | RL | Fluid volume administered | Surrogate | 28 |
Bedi et al. [46] | 2019 | RCT | 1 | 200 | TBSA > 30% | Dextrose + 0.9% normal saline | RL | Serum sodium | Surrogate | 3 |
Belba et al. [47] | 2009 | RCT | 1 | 110 | TBSA > 20% adults, > 15% children | Hypertonic lactate saline | RL | Cumulative fluid balance | Surrogate | 1 |
Bortolani et al. [48] | 1996 | RCT | 1 | 40 | TBSA > 30% | Hypertonic lactate saline | RL | Fluid volumes administered | Surrogate | 4 |
Cooper et al. [49] | 2006 | RCT | 3 | 42 | TBSA > 20% | 5% albumin | RL | Difference in MODS between groups | Surrogate | 28 |
Goodwin et al. [50] | 1983 | RCT | 1 | 79 | TBSA unknown | Albumin-Ringer’s solution | RL | Cardiac output | Surrogate | 7 |
Gunn et al. [51] | 1989 | RCT | 1 | 51 | > 20% TBSA | Hypertonic lactate saline | RL | Fluid volume administered | Surrogate | 3 |
Hall et al. [52] | 1978 | RCT | 1 | 172 | TBSA > 15% adults, > 10% children | Dextran 70 | RL | Urine output | Surrogate | 3 |
Huang et al. [53] | 2005 | RCT | 1 | 20 | TBSA > 40% | Delayed rapid colloid resuscitation | No rapid fluid resuscitation | Fluid volume administered | Surrogate | 2 |
Sudhakar et al. [54] | 2008 | RCT | 1 | 32 | TBSA 30–70% | Hydroxyethyl starch 130/0.4 + RL | RL | Urine output | Surrogate | 2 |
Vlachou et al. [55] | 2010 | RCT | 1 | 26 | TBSA 15–80% | 6% hydroxyethyl starch + RL | RL | Fluid balance | Surrogate | 2 |
Waxman et al. [56] | 1989 | RCT | 1 | 12 | TBSA > 25% | 10% pentastarch | 5% albumin | Haemodynamic parameters | Surrogate | < 1 |
Aoki et al. [57] | 2010 | Pseudo RCT | 2 | 20 | TBSA > 30% | RA | RL | Gastric CO2 | Surrogate | 3 |
O'mara et al. [58] | 2005 | Pseudo RCT | 1 | 31 | TBSA > 40% without inhalational injury OR TBSA > 25% with inhalational injury | RL and FFP | RL | IAP > 25 mmHg | Surrogate | 5 |
Tanaka et al. [59] | 2000 | Pseudo RCT | 1 | 37 | TBSA > 30% | IV ascorbic acid + RL | RL | Fluid volume administered | Surrogate | 36 |
Bechir et al. [60] | 2010 | CSWCC | 1 | 30 | TBSA unknown | Hydroxyethyl starch + RL | RL | Fluid volume administered | Surrogate | 60 |
Bocanegra et al. [61] | 1966 | CSWCC | 1 | 308 | TBSA > 10% | Colloid-plus-glucose or saline-plus-plasma | NS | Shock mortality | Patient-centred | 36 |
Chung et al. [62] | 2009 | CSWCC | 1 | 52 | TBSA > 20% | Brooke formula | Parkland formula | Fluid volume administered | Surrogate | 1 |
Jelenko et al. [63] | 1978 | CSWCC | 1 | 19 | TBSA > 40% | Hypertonic albumin solution | 2 groups—(A) RL, (H) hypertonic solution | Weight change | Surrogate | 5 |
Murphy et al. [64] | 1999 | CSWCC | 1 | 18 | TBSA > 40% | RL and 7.5% hypertonic saline-dextran solution | Ringer’s lactate only | Cardiac output parameters as measured by PA catheter | Surrogate | 1 |
Oda et al. [65] | 2006 | CSWCC | 1 | 36 | TBSA > 40% | Hypertonic lactate saline | RL | Fluid volume administered | Surrogate | 3 |
Aboelatta et al. [66] | 2013 | ISWCC | 2 | 30 | TBSA 25–60% | Fluid resuscitation guided by PICCO | Parkland formula | Fluid volume administered | Surrogate | 3 |
Arlati et al. [67] | 2006 | ISWCC | 1 | 24 | TBSA > 20% | Permissive hypovolaemia | Parkland formula | MODS | Surrogate | NA |
Berger et al. [68] | 2000 | ISWCC | 1 | 40 | TBSA > 25% | Bicarbonated 0.9% saline (340 mmol) solution | RL | Mortality | Patient-centred | 10 |
Gille et al. [69] | 2014 | ISWCC | 1 | 80 | TBSA > 20% | RA | RL | SOFA score | Surrogate | 60 |
Salinas et al. [70] | 2011 | ISWCC | 1 | 70 | TBSA > 20% | Computer led algorithm | Parkland formula | Total crystalloid volume in first 48 h | Surrogate | NA |